Artificial supplements for diabetes prevention: hype or hope?
Definitely, CrPic therapy is solely one example of several therapy forms which currently are applied ‘across-the-board’ in diabetes care. The administration of artificial supplements is an attempt to prevent or at least to postpone the onset of type 2 diabetes in the group of risk and with individuals who are unwilling to make prudent changes in their diets and sedentary habits. Should this approach be considered as the hype or the hope? Considering type 2 diabetes as a multifactorial disease, our answer is that the above question is rather of rhetoric nature.
High efficacy of a balanced diet, an individually optimised lifestyle and personalised treatment regiments can hardly be substituted by a limited number of single supplements to cover all the multifactorial risks such as the upward trends of population ageing, environmental risk factors, urbanisation, additive effects of diverse stress factors, incorrectly chosen lifestyle including unfavourable nutritional habits, increasing prevalence of obesity, low physical activity, etc.
Although ageing is the well-acknowledged factor contributing to the disease’s development, there are completely new epidemiologic factors characteristic of the twenty-first century that speed up the disease’s progression particularly in the youth and in the young adults. Hence, it has been demonstrated that the prognosed DM rate progression will be inversely increasing with age (younger age = higher progression), and the youngest group of 20–39-year-old people will be delivering the highest rates of diabetic progression which will double the diabetes mellitus cohort of this age group by the year 2030 compared to 2010
. This is a completely new situation and a very big challenge for most societies around the globe, requiring special competencies of several groups of professionals as well as innovative approaches in healthcare and health economy.
The population at-risk for diabetes is huge and increasing in a pandemic scale. One of the reasons might be the failed attempt to prevent the disease by the application of artificial supplements and drugs with hardly recognised individual risks. Consequently, a multimodal approach of integrative medicine by predictive diagnostics, targeted prevention and individually created treatment algorithms is highly desirable.
As discussed and reviewed earlier, more individualised treatments are desirable in effective protection against diabetic retinopathy and polyneuropathy, diabetes-related cardiovascular complications and cancer
. Further, field-related research is needed to establish simplified non-invasive diagnostic approaches for routine medical practice which would allow for an accurate prediction of individualised therapy risks and outcomes. A promising technological platform has been recently created using the detection of circulating nucleic acids in blood plasma
 and clinical proteomics of body fluids
Targeted measures require a creation of new guidelines that are essential to regulate (renoprotective) therapy approaches and the application of more individualised therapeutic modalities for advanced diabetes care. These measures should provide a legitimate regulation for well-timed predictive diagnostics, an effective prevention and the creation of individualised treatment algorithms in pre/diabetes